@article {19896,
	title = {Genetic variation of habitual coffee consumption and glycemic changes in response to weight-loss diet intervention: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial},
	journal = {Am J Clin NutrAm J Clin NutrAm J Clin Nutr},
	volume = {106},
	number = {5},
	year = {2017},
	note = {Han, LiyuanMa, WenjieSun, DianjianyiHeianza, YorikoWang, TiangeZheng, YanHuang, TaoDuan, DonghuiBray, J George AChampagne, Catherine MSacks, Frank MQi, LuAm J Clin Nutr. 2017 Nov;106(5):1321-1326. doi: 10.3945/ajcn.117.156232. Epub 2017 Sep 20.},
	month = {Nov},
	pages = {1321-1326},
	type = {Randomized Controlled Trial},
	edition = {2017/09/22},
	abstract = {Background: Coffee consumption has been associated with glucose metabolism and risk of type 2 diabetes.Objective: We examined whether the genetic variation determining habitual coffee consumption affected glycemic changes in response to weight-loss dietary intervention.Design: A genetic risk score (GRS) was calculated based on 8 habitual coffee consumption-associated single nucleotide polymorphisms. We used general linear models to test changes in glycemic traits in groups randomly assigned to high- and low-fat diets according to tertiles of the GRS.Results: We observed significant interactions between the GRS and low compared with high dietary fat intake on 6-mo changes in fasting insulin and homeostasis model assessment of insulin resistance (HOMA-IR) (P-interaction = 0.023 and 0.022, respectively), adjusting for age, sex, race, physical activity, smoking, alcohol, seasonal variation, and baseline values of the respective outcomes. Participants with a higher GRS of habitual coffee consumption showed a greater reduction in fasting insulin and a marginally greater decrease in HOMA-IR in the low-fat diet intervention group.Conclusions: Our data suggest that participants with genetically determined high coffee consumption may benefit more by eating a low-fat diet in improving fasting insulin and HOMA-IR in a short term. This trial was registered at clinicaltrials.gov as NCT00072995 and NCT03258203.},
	keywords = {*Coffee, *Diet, Reducing, *Polymorphism, Single Nucleotide, Adult, Aged, Blood Glucose/*metabolism, Body Mass Index, Cluster Analysis, Diet, Fat-Restricted, Dietary Fats/administration \& dosage, Exercise, Female, Follow-Up Studies, Humans, Insulin Resistance, Insulin/blood, Linear Models, Male, Middle Aged, Overweight/*prevention \& control, Patient Compliance},
	isbn = {1938-3207 (Electronic)0002-9165 (Linking)},
	author = {Han, L. and W. Ma and Sun, D. and Heianza, Y. and T. Wang and Zheng, Y. and Huang, T. and Duan, D. and Bray, J. G. A. and Champagne, C. M. and Sacks, F. M. and Qi, L.}
}
