@article {19895,
	title = {Starch Digestion-Related Amylase Genetic Variant Affects 2-Year Changes in Adiposity in Response to Weight-Loss Diets: The POUNDS Lost Trial},
	journal = {DiabetesDiabetesDiabetes},
	volume = {66},
	number = {9},
	year = {2017},
	note = {Heianza, YorikoSun, DianjianyiWang, TiangeHuang, TaoBray, George ASacks, Frank MQi, LuR01 DK078616/DK/NIDDK NIH HHS/R01 DK091718/DK/NIDDK NIH HHS/P30 DK046200/DK/NIDDK NIH HHS/R21 HL126024/HL/NHLBI NIH HHS/R01 HL034594/HL/NHLBI NIH HHS/U01 DK078616/DK/NIDDK NIH HHS/R01 DK100383/DK/NIDDK NIH HHS/R01 HL071981/HL/NHLBI NIH HHS/Diabetes. 2017 Sep;66(9):2416-2423. doi: 10.2337/db16-1482. Epub 2017 Jun 28.},
	month = {Sep},
	pages = {2416-2423},
	type = {Randomized Controlled TrialResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov\&$\#$039;t},
	edition = {2017/07/01},
	abstract = {Salivary and pancreatic amylases (encoded by AMY1 and AMY2 genes, respectively) are responsible for digesting starchy foods. AMY1 and AMY2 show copy number variations that affect differences in amylase amount and activity, and AMY1 copies have been associated with adiposity. We investigated whether genetic variants determining amylase gene copies are associated with 2-year changes in adiposity among 692 overweight and obese individuals who were randomly assigned to diets varying in macronutrient content. We found that changes in body weight (BW) and waist circumference (WC) were significantly different according to the AMY1-AMY2 rs11185098 genotype. Individuals carrying the A allele (indicating higher amylase amount and activity) showed a greater reduction in BW and WC at 6, 12, 18, and 24 months than those without the A allele (P \&lt; 0.05 for all). The association was stronger for long-term changes compared with short-term changes of these outcomes. The genetic effects on these outcomes did not significantly differ across diet groups. In conclusion, the genetic variant determining starch metabolism influences the response to weight-loss dietary intervention. Overweight and obese individuals carrying the AMY1-AMY2 rs11185098 genotype associated with higher amylase activity may have greater loss of adiposity during low-calorie diet interventions.},
	keywords = {*Genetic Variation, Adiposity, Adult, biomarkers, Diet, Reducing, DNA-Binding Proteins/genetics/*metabolism, Female, Gene Expression Regulation, Enzymologic, Genotype, Humans, Male, Middle Aged, Obesity/*diet therapy/*genetics, Pancreatic alpha-Amylases/genetics/*metabolism, Transcription Factors/genetics/*metabolism},
	isbn = {1939-327X (Electronic)0012-1797 (Linking)},
	author = {Heianza, Y. and Sun, D. and T. Wang and Huang, T. and Bray, G. A. and Sacks, F. M. and Qi, L.}
}
