@article {19893,
	title = {Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits},
	journal = {Nat CommunNat CommunNat Commun},
	volume = {8},
	year = {2017},
	note = {Justice, Anne EWinkler, Thomas WFeitosa, Mary FGraff, MisaFisher, Virginia AYoung, KristinBarata, LlildaDeng, XuanCzajkowski, JacekHadley, DavidNgwa, Julius SAhluwalia, Tarunveer SChu, Audrey YHeard-Costa, Nancy LLim, ElisePerez, JeremiahEicher, John DKutalik, ZoltanXue, LutingMahajan, AnubhaRenstrom, FridaWu, JosephQi, QibinAhmad, ShafqatAlfred, TamunoAmin, NajafBielak, Lawrence FBonnefond, AmelieBragg, JenniferCadby, GemmaChittani, MartinaCoggeshall, ScottCorre, TanguyDirek, NeseEriksson, JoelFischer, KristaGorski, MathiasNeergaard Harder, MarieHorikoshi, MomokoHuang, TaoHuffman, Jennifer EJackson, Anne UJustesen, Johanne MarieKanoni, StavroulaKinnunen, LeenaKleber, Marcus EKomulainen, PirjoKumari, MeenaLim, UnheeLuan, Jian\&$\#$039;anLyytikainen, Leo-PekkaMangino, MassimoManichaikul, AniMarten, JonathanMiddelberg, Rita P SMuller-Nurasyid, MartinaNavarro, PauPerusse, LouisPervjakova, NataliaSarti, CinziaSmith, Albert VernonSmith, Jennifer AStancakova, AlenaStrawbridge, Rona JStringham, Heather MSung, Yun JuTanaka, ToshikoTeumer, AlexanderTrompet, Stellavan der Laan, Sander Wvan der Most, Peter JVan Vliet-Ostaptchouk, Jana VVedantam, Sailaja LVerweij, NiekVink, Jacqueline MVitart, VeroniqueWu, YingYengo, LoicZhang, WeihuaHua Zhao, JingZimmermann, Martina EZubair, NihaAbecasis, Goncalo RAdair, Linda SAfaq, SaimaAfzal, UzmaBakker, Stephan J LBartz, Traci MBeilby, JohnBergman, Richard NBergmann, SvenBiffar, ReinerBlangero, JohnBoerwinkle, EricBonnycastle, Lori LBottinger, ErwinBraga, DanieleBuckley, Brendan MBuyske, SteveCampbell, HarryChambers, John CCollins, Francis SCurran, Joanne Ede Borst, Gert Jde Craen, Anton J Mde Geus, Eco J CDedoussis, GeorgeDelgado, Graciela Eden Ruijter, Hester MEiriksdottir, GudnyEriksson, Anna LEsko, TonuFaul, Jessica DFord, IanForrester, TerrenceGertow, KarlGigante, BrunaGlorioso, NicolaGong, JianGrallert, HaraldGrammer, Tanja BGrarup, NielsHaitjema, SaskiaHallmans, GoranHamsten, AndersHansen, TorbenHarris, Tamara BHartman, Catharina AHassinen, MaijaHastie, Nicholas DHeath, Andrew CHernandez, DenaHindorff, LuciaHocking, Lynne JHollensted, MetteHolmen, Oddgeir LHomuth, GeorgJan Hottenga, JoukeHuang, JieHung, JosephHutri-Kahonen, NinaIngelsson, ErikJames, Alan LJansson, John-OlovJarvelin, Marjo-RiittaJhun, Min AJorgensen, Marit EJuonala, MarkusKahonen, MikaKarlsson, MagnusKoistinen, Heikki AKolcic, IvanaKolovou, GenovefaKooperberg, CharlesKramer, Bernhard KKuusisto, JohannaKvaloy, KirstiLakka, Timo ALangenberg, ClaudiaLauner, Lenore JLeander, KarinLee, Nanette RLind, LarsLindgren, Cecilia MLinneberg, AllanLobbens, StephaneLoh, MarieLorentzon, MattiasLuben, RobertLubke, GittaLudolph-Donislawski, AnjaLupoli, SaraMadden, Pamela A FMannikko, ReijaMarques-Vidal, PedroMartin, Nicholas GMcKenzie, Colin AMcKnight, BarbaraMellstrom, DanMenni, CristinaMontgomery, Grant WMusk, Aw BillNarisu, NarisuNauck, MatthiasNolte, Ilja MOldehinkel, Albertine JOlden, MatthiasOng, Ken KPadmanabhan, SandoshPeyser, Patricia APisinger, CharlottaPorteous, David JRaitakari, Olli TRankinen, TuomoRao, D CRasmussen-Torvik, Laura JRawal, RajeshRice, TrevaRidker, Paul MRose, Lynda MBien, Stephanie ARudan, IgorSanna, SerenaSarzynski, Mark ASattar, NaveedSavonen, KaiSchlessinger, DavidScholtens, SalomeSchurmann, ClaudiaScott, Robert ASennblad, BengtSiemelink, Marten ASilbernagel, GuntherSlagboom, P ElineSnieder, HaroldStaessen, Jan AStott, David JSwertz, Morris ASwift, Amy JTaylor, Kent DTayo, Bamidele OThorand, BarbaraThuillier, DorotheeTuomilehto, JaakkoUitterlinden, Andre GVandenput, LiesbethVohl, Marie-ClaudeVolzke, HenryVonk, Judith MWaeber, GerardWaldenberger, MelanieWestendorp, R G JWild, SarahWillemsen, GonnekeWolffenbuttel, Bruce H RWong, AndrewWright, Alan FZhao, WeiZillikens, M CarolaBaldassarre, DamianoBalkau, BeverleyBandinelli, StefaniaBoger, Carsten ABoomsma, Dorret IBouchard, ClaudeBruinenberg, MarcelChasman, Daniel IChen, Yii-DerIdaChines, Peter SCooper, Richard SCucca, FrancescoCusi, DanieleFaire, Ulf deFerrucci, LuigiFranks, Paul WFroguel, PhilippeGordon-Larsen, PennyGrabe, Hans-JorgenGudnason, VilmundurHaiman, Christopher AHayward, CarolineHveem, KristianJohnson, Andrew DWouter Jukema, JKardia, Sharon L RKivimaki, MikaKooner, Jaspal SKuh, DianaLaakso, MarkkuLehtimaki, TerhoMarchand, Loic LeMarz, WinfriedMcCarthy, Mark IMetspalu, AndresMorris, Andrew POhlsson, ClaesPalmer, Lyle JPasterkamp, GerardPedersen, OlufPeters, AnnettePeters, UlrikePolasek, OzrenPsaty, Bruce MQi, LuRauramaa, RainerSmith, Blair HSorensen, Thorkild I AStrauch, KonstantinTiemeier, HenningTremoli, Elenavan der Harst, PimVestergaard, HenrikVollenweider, PeterWareham, Nicholas JWeir, David RWhitfield, John BWilson, James FTyrrell, JessicaFrayling, Timothy MBarroso, InesBoehnke, MichaelDeloukas, PanagiotisFox, Caroline SHirschhorn, Joel NHunter, David JSpector, Tim DStrachan, David Pvan Duijn, Cornelia MHeid, Iris MMohlke, Karen LMarchini, JonathanLoos, Ruth J FKilpelainen, Tuomas OLiu, Ching-TiBorecki, Ingrid BNorth, Kari ECupples, L AdrienneR01 DK093757/DK/NIDDK NIH HHS/N01HC55020/HL/NHLBI NIH HHS/R01 DK078616/DK/NIDDK NIH HHS/RC2 MH089951/MH/NIMH NIH HHS/RC4 AG039029/AG/NIA NIH HHS/R01 HL053353/HL/NHLBI NIH HHS/G1001799/Medical Research Council/United KingdomR01 HL103612/HL/NHLBI NIH HHS/HHSN268201100001I/HL/NHLBI NIH HHS/K99 HL130580/HL/NHLBI NIH HHS/R01 AA007535/AA/NIAAA NIH HHS/P30 ES010126/ES/NIEHS NIH HHS/N01AG12100/AG/NIA NIH HHS/R01 AA014041/AA/NIAAA NIH HHS/R01 MH081802/MH/NIMH NIH HHS/K05 AA017688/AA/NIAAA NIH HHS/N01HC95160/HL/NHLBI NIH HHS/N01HG65403/HG/NHGRI NIH HHS/R01 HL120393/HL/NHLBI NIH HHS/R01 MH066206/MH/NIMH NIH HHS/R03 AG046389/AG/NIA NIH HHS/U01 HL084729/HL/NHLBI NIH HHS/UL1 RR025005/RR/NCRR NIH HHS/T32 EY022303/EY/NEI NIH HHS/U01 AG009740/AG/NIA NIH HHS/N01HC95163/HL/NHLBI NIH HHS/U01 HL080295/HL/NHLBI NIH HHS/HHSN268201500001C/HL/NHLBI NIH HHS/U01 HG004790/HG/NHGRI NIH HHS/UL1 TR001079/TR/NCATS NIH HHS/P50 AA011998/AA/NIAAA NIH HHS/R01 HG002651/HG/NHGRI NIH 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HL119443/HL/NHLBI NIH HHS/R01 DK062370/DK/NIDDK NIH HHS/R01 HL105756/HL/NHLBI NIH HHS/N01HC95168/HL/NHLBI NIH HHS/R01 HL118305/HL/NHLBI NIH HHS/R01 AA013321/AA/NIAAA NIH HHS/R37 AG013196/AG/NIA NIH HHS/U10 HL054457/HL/NHLBI NIH HHS/MR/N01104X/1/Medical Research Council/United KingdomP30 DK046200/DK/NIDDK NIH HHS/U01 DK062418/DK/NIDDK NIH HHS/P30 DK063491/DK/NIDDK NIH HHS/MC_UU_12015/2/Medical Research Council/United KingdomR21 HL126024/HL/NHLBI NIH HHS/HHSN268201200036C/HL/NHLBI NIH HHS/U01 HL054457/HL/NHLBI NIH HHS/HHSN271201100004C/AG/NIA NIH HHS/N01HC95165/HL/NHLBI NIH HHS/N01HC95159/HL/NHLBI NIH HHS/P01 CA033619/CA/NCI NIH HHS/HHSN268201500001I/HL/NHLBI NIH HHS/R01 LM010098/LM/NLM NIH HHS/R01 HL034594/HL/NHLBI NIH HHS/N01HC95161/HL/NHLBI NIH HHS/HHSN268201100002C/WH/WHI NIH HHS/N01HC55016/HL/NHLBI NIH HHS/MC_PC_U127561128/Medical Research Council/United KingdomU24 MH068457/MH/NIMH NIH HHS/UM1 CA182913/CA/NCI NIH HHS/R01 DA012854/DA/NIDA NIH HHS/U01 DK078616/DK/NIDDK NIH HHS/R01 DK100383/DK/NIDDK NIH HHS/R01 HL071981/HL/NHLBI NIH HHS/R01 CA047988/CA/NCI NIH HHS/N01HC55019/HL/NHLBI NIH HHS/R01 HL080467/HL/NHLBI NIH HHS/N01HC85082/HL/NHLBI NIH HHS/R01 HL085144/HL/NHLBI NIH HHS/R01 DK089256/DK/NIDDK NIH HHS/N01HC95167/HL/NHLBI NIH HHS/R01 AG013196/AG/NIA NIH HHS/U01 CA098758/CA/NCI NIH HHS/N01HC85083/HL/NHLBI NIH HHS/N01HC25195/HL/NHLBI NIH HHS/R01 DA018673/DA/NIDA NIH HHS/P30 DK056350/DK/NIDDK NIH HHS/P30 DK020572/DK/NIDDK NIH HHS/S10 OD020069/OD/NIH HHS/RG/14/5/30893/British Heart Foundation/United KingdomR01 TW008288/TW/FIC NIH HHS/UL1 TR000040/TR/NCATS NIH HHS/RC2 AG036495/AG/NIA NIH HHS/Wellcome Trust/United KingdomR01 HD057194/HD/NICHD NIH HHS/HHSN268201100002I/HL/NHLBI NIH HHS/Z01 HG000024/HG/NHGRI NIH HHS/N01HC85079/HL/NHLBI NIH HHS/N01HC95166/HL/NHLBI NIH HHS/R01 HL117078/HL/NHLBI NIH HHS/N01HC55021/HL/NHLBI NIH HHS/R01 AG023629/AG/NIA NIH HHS/R01 HL087641/HL/NHLBI NIH HHS/UL1 TR001881/TR/NCATS NIH HHS/P2C HD050924/HD/NICHD NIH HHS/T32 HL007055/HL/NHLBI NIH HHS/U01 CA136792/CA/NCI NIH HHS/N01HC85080/HL/NHLBI NIH HHS/R37 CA054281/CA/NCI NIH HHS/HHSN268201100001C/WH/WHI NIH HHS/N01WH22110/WH/WHI NIH HHS/R01 DK078150/DK/NIDDK NIH HHS/HHSN268201100004C/WH/WHI NIH HHS/R01 AA013320/AA/NIAAA NIH HHS/N01HC85081/HL/NHLBI NIH HHS/R01 HL045670/HL/NHLBI NIH HHS/RG/10/12/28456/British Heart Foundation/United KingdomEnglandNat Commun. 2017 Apr 26;8:14977. doi: 10.1038/ncomms14977.},
	month = {Apr 26},
	pages = {14977},
	type = {Meta-AnalysisResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov\&$\#$039;t},
	edition = {2017/04/27},
	abstract = {Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87\% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.},
	keywords = {Adiposity/genetics, Adult, Body Fat Distribution, Body Mass Index, Epistasis, Genetic, Genetic Predisposition to Disease/*genetics, Genome-Wide Association Study/*methods, Humans, Obesity/*genetics, Phenotype, Polymorphism, Single Nucleotide, Quantitative Trait Loci/*genetics, Smoking/*genetics, Waist Circumference/genetics, Waist-Hip Ratio},
	isbn = {2041-1723 (Electronic)2041-1723 (Linking)},
	author = {Justice, A. E. and Winkler, T. W. and Feitosa, M. F. and Graff, M. and Fisher, V. A. and Young, K. and Barata, L. and Deng, X. and Czajkowski, J. and Hadley, D. and Ngwa, J. S. and Ahluwalia, T. S. and Chu, A. Y. and Heard-Costa, N. L. and Lim, E. and Perez, J. and Eicher, J. D. and Kutalik, Z. and Xue, L. and Mahajan, A. and Renstrom, F. and J. Wu and Qi, Q. and Ahmad, S. and Alfred, T. and Amin, N. and Bielak, L. F. and Bonnefond, A. and Bragg, J. and Cadby, G. and Chittani, M. and Coggeshall, S. and Corre, T. and Direk, N. and Eriksson, J. and Fischer, K. and Gorski, M. and Neergaard Harder, M. and Horikoshi, M. and Huang, T. and Huffman, J. E. and Jackson, A. U. and Justesen, J. M. and Kanoni, S. and Kinnunen, L. and Kleber, M. E. and Komulainen, P. and Kumari, M. and Lim, U. and Luan, J. and Lyytikainen, L. P. and Mangino, M. and Manichaikul, A. and Marten, J. and Middelberg, R. P. S. and Muller-Nurasyid, M. and Navarro, P. and Perusse, L. and Pervjakova, N. and Sarti, C. and Smith, A. V. and Smith, J. A. and Stancakova, A. and Strawbridge, R. J. and Stringham, H. M. and Sung, Y. J. and Tanaka, T. and Teumer, A. and Trompet, S. and van der Laan, S. W. and van der Most, P. J. and Van Vliet-Ostaptchouk, J. V. and Vedantam, S. L. and Verweij, N. and Vink, J. M. and Vitart, V. and Wu, Y. and Yengo, L. and W. Zhang and Hua Zhao, J. and Zimmermann, M. E. and Zubair, N. and Abecasis, G. R. and Adair, L. S. and Afaq, S. and Afzal, U. and Bakker, S. J. L. and Bartz, T. M. and Beilby, J. and Bergman, R. N. and Bergmann, S. and Biffar, R. and Blangero, J. and Boerwinkle, E. and Bonnycastle, L. L. and Bottinger, E. and Braga, D. and Buckley, B. M. and Buyske, S. and Campbell, H. and Chambers, J. C. and Collins, F. S. and Curran, J. E. and de Borst, G. J. and de Craen, A. J. M. and de Geus, E. J. C. and Dedoussis, G. and Delgado, G. E. and den Ruijter, H. M. and Eiriksdottir, G. and Eriksson, A. L. and Esko, T. and Faul, J. D. and Ford, I. and Forrester, T. and Gertow, K. and Gigante, B. and Glorioso, N. and Gong, J. and Grallert, H. and Grammer, T. B. and Grarup, N. and Haitjema, S. and Hallmans, G. and Hamsten, A. and Hansen, T. and Harris, T. B. and Hartman, C. A. and Hassinen, M. and Hastie, N. D. and Heath, A. C. and Hernandez, D. and Hindorff, L. and Hocking, L. J. and Hollensted, M. and Holmen, O. L. and Homuth, G. and Jan Hottenga, J. and Huang, J. and Hung, J. and Hutri-Kahonen, N. and Ingelsson, E. and James, A. L. and Jansson, J. O. and Jarvelin, M. R. and Jhun, M. A. and Jorgensen, M. E. and Juonala, M. and Kahonen, M. and Karlsson, M. and Koistinen, H. A. and Kolcic, I. and Kolovou, G. and Kooperberg, C. and Kramer, B. K. and Kuusisto, J. and Kvaloy, K. and Lakka, T. A. and Langenberg, C. and Launer, L. J. and Leander, K. and Lee, N. R. and Lind, L. and Lindgren, C. M. and Linneberg, A. and Lobbens, S. and Loh, M. and Lorentzon, M. and Luben, R. and Lubke, G. and Ludolph-Donislawski, A. and Lupoli, S. and Madden, P. A. F. and Mannikko, R. and Marques-Vidal, P. and Martin, N. G. and McKenzie, C. A. and McKnight, B. and Mellstrom, D. and Menni, C. and Montgomery, G. W. and Musk, A. B. and Narisu, N. and Nauck, M. and Nolte, I. M. and Oldehinkel, A. J. and Olden, M. and Ong, K. K. and Padmanabhan, S. and Peyser, P. A. and Pisinger, C. and Porteous, D. J. and Raitakari, O. T. and Rankinen, T. and Rao, D. C. and Rasmussen-Torvik, L. J. and Rawal, R. and Rice, T. and Ridker, P. M. and Rose, L. M. and Bien, S. A. and Rudan, I. and Sanna, S. and Sarzynski, M. A. and Sattar, N. and Savonen, K. and Schlessinger, D. and Scholtens, S. and Schurmann, C. and Scott, R. A. and Sennblad, B. and Siemelink, M. A. and Silbernagel, G. and Slagboom, P. E. and Snieder, H. and Staessen, J. A. and Stott, D. J. and Swertz, M. A. and Swift, A. J. and Taylor, K. D. and Tayo, B. O. and Thorand, B. and Thuillier, D. and Tuomilehto, J. and Uitterlinden, A. G. and Vandenput, L. and Vohl, M. C. and Volzke, H. and Vonk, J. M. and Waeber, G. and Waldenberger, M. and Westendorp, R. G. J. and Wild, S. and Willemsen, G. and Wolffenbuttel, B. H. R. and Wong, A. and Wright, A. F. and Zhao, W. and Zillikens, M. C. and Baldassarre, D. and Balkau, B. and Bandinelli, S. and Boger, C. A. and Boomsma, D. I. and Bouchard, C. and Bruinenberg, M. and Chasman, D. I. and Chen, Y. D. and Chines, P. S. and Cooper, R. S. and Cucca, F. and Cusi, D. and Faire, U. and Ferrucci, L. and Franks, P. W. and Froguel, P. and Gordon-Larsen, P. and Grabe, H. J. and Gudnason, V. and Haiman, C. A. and Hayward, C. and Hveem, K. and Johnson, A. D. and Wouter Jukema, J. and Kardia, S. L. R. and Kivimaki, M. and Kooner, J. S. and Kuh, D. and Laakso, M. and Lehtimaki, T. and Marchand, L. L. and Marz, W. and McCarthy, M. I. and Metspalu, A. and Morris, A. P. and Ohlsson, C. and Palmer, L. J. and Pasterkamp, G. and Pedersen, O. and Peters, A. and Peters, U. and Polasek, O. and Psaty, B. M. and Qi, L. and Rauramaa, R. and Smith, B. H. and Sorensen, T. I. A. and Strauch, K. and Tiemeier, H. and Tremoli, E. and van der Harst, P. and Vestergaard, H. and Vollenweider, P. and Wareham, N. J. and Weir, D. R. and Whitfield, J. B. and Wilson, J. F. and Tyrrell, J. and Frayling, T. M. and Barroso, I. and Boehnke, M. and Deloukas, P. and Fox, C. S. and Hirschhorn, J. N. and Hunter, D. J. and Spector, T. D. and Strachan, D. P. and van Duijn, C. M. and Heid, I. M. and Mohlke, K. L. and Marchini, J. and Loos, R. J. F. and Kilpelainen, T. O. and Liu, C. T. and Borecki, I. B. and North, K. E. and Cupples, L. A.}
}
