@article {19871,
	title = {Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium},
	journal = {Mol PsychiatryMol PsychiatryMol Psychiatry},
	year = {2018},
	note = {Merino, JordiDashti, Hassan SLi, Sherly XSarnowski, ChloeJustice, Anne EGraff, MisaPapoutsakis, ConstantinaSmith, Caren EDedoussis, George VLemaitre, Rozenn NWojczynski, Mary KMannisto, SatuNgwa, Julius SKho, MinjungAhluwalia, Tarunveer SPervjakova, NataliaHouston, Denise KBouchard, ClaudeHuang, TaoOrho-Melander, MarjuFrazier-Wood, Alexis CMook-Kanamori, Dennis OPerusse, LouisPennell, Craig Ede Vries, Paul SVoortman, TrudyLi, OliviaKanoni, StavroulaRose, Lynda MLehtimaki, TerhoZhao, Jing HuaFeitosa, Mary FLuan, Jian\&$\#$039;anMcKeown, Nicola MSmith, Jennifer AHansen, TorbenEklund, NiinaNalls, Mike ARankinen, TuomoHuang, JinyanHernandez, Dena GSchulz, Christina-AlexandraManichaikul, AniLi-Gao, RuifangVohl, Marie-ClaudeWang, Carol Avan Rooij, Frank J AShin, JeanKalafati, Ioanna PDay, FelixRidker, Paul MKahonen, MikaSiscovick, David SLangenberg, ClaudiaZhao, WeiAstrup, ArneKnekt, PaulGarcia, MelissaRao, D CQi, QibinFerrucci, LuigiEricson, UlrikaBlangero, JohnHofman, AlbertPausova, ZdenkaMikkila, VeraWareham, Nick JKardia, Sharon L RPedersen, OlufJula, AnttiCurran, Joanne EZillikens, M CarolaViikari, Jorma SForouhi, Nita GOrdovas, Jose MLieske, John CRissanen, HarriUitterlinden, Andre GRaitakari, Olli TKiefte-de Jong, Jessica CDupuis, JoseeRotter, Jerome INorth, Kari EScott, Robert AProvince, Michael APerola, MarkusCupples, L AdrienneTurner, Stephen TSorensen, Thorkild I ASalomaa, VeikkoLiu, YongmeiSung, Yun JQi, LuBandinelli, StefaniaRich, Stephen Sde Mutsert, ReneeTremblay, AngeloOddy, Wendy HFranco, Oscar HPaus, TomasFlorez, Jose CDeloukas, PanosLyytikainen, Leo-PekkaChasman, Daniel IChu, Audrey YTanaka, ToshikoN01 HC025195/HC/WHI NIH HHS/T32 EY022303/EY/NEI NIH HHS/EnglandMol Psychiatry. 2018 Jul 9. pii: 10.1038/s41380-018-0079-4. doi: 10.1038/s41380-018-0079-4.},
	month = {Jul 9},
	edition = {2018/07/11},
	abstract = {Macronutrient intake, the proportion of calories consumed from carbohydrate, fat, and protein, is an important risk factor for metabolic diseases with significant familial aggregation. Previous studies have identified two genetic loci for macronutrient intake, but incomplete coverage of genetic variation and modest sample sizes have hindered the discovery of additional loci. Here, we expanded the genetic landscape of macronutrient intake, identifying 12 suggestively significant loci (P \&lt; 1 x 10(-6)) associated with intake of any macronutrient in 91,114 European ancestry participants. Four loci replicated and reached genome-wide significance in a combined meta-analysis including 123,659 European descent participants, unraveling two novel loci; a common variant in RARB locus for carbohydrate intake and a rare variant in DRAM1 locus for protein intake, and corroborating earlier FGF21 and FTO findings. In additional analysis of 144,770 participants from the UK Biobank, all identified associations from the two-stage analysis were confirmed except for DRAM1. Identified loci might have implications in brain and adipose tissue biology and have clinical impact in obesity-related phenotypes. Our findings provide new insight into biological functions related to macronutrient intake.},
	isbn = {1476-5578 (Electronic)1359-4184 (Linking)},
	author = {Merino, J. and Dashti, H. S. and Li, S. X. and Sarnowski, C. and Justice, A. E. and Graff, M. and Papoutsakis, C. and Smith, C. E. and Dedoussis, G. V. and Lemaitre, R. N. and Wojczynski, M. K. and Mannisto, S. and Ngwa, J. S. and Kho, M. and Ahluwalia, T. S. and Pervjakova, N. and Houston, D. K. and Bouchard, C. and Huang, T. and Orho-Melander, M. and Frazier-Wood, A. C. and Mook-Kanamori, D. O. and Perusse, L. and Pennell, C. E. and de Vries, P. S. and Voortman, T. and Li, O. and Kanoni, S. and Rose, L. M. and Lehtimaki, T. and Zhao, J. H. and Feitosa, M. F. and Luan, J. and McKeown, N. M. and Smith, J. A. and Hansen, T. and Eklund, N. and Nalls, M. A. and Rankinen, T. and Huang, J. and Hernandez, D. G. and Schulz, C. A. and Manichaikul, A. and Li-Gao, R. and Vohl, M. C. and Wang, C. A. and van Rooij, F. J. A. and J. Shin and Kalafati, I. P. and Day, F. and Ridker, P. M. and Kahonen, M. and Siscovick, D. S. and Langenberg, C. and Zhao, W. and Astrup, A. and Knekt, P. and Garcia, M. and Rao, D. C. and Qi, Q. and Ferrucci, L. and Ericson, U. and Blangero, J. and Hofman, A. and Pausova, Z. and Mikkila, V. and Wareham, N. J. and Kardia, S. L. R. and Pedersen, O. and Jula, A. and Curran, J. E. and Zillikens, M. C. and Viikari, J. S. and Forouhi, N. G. and Ordovas, J. M. and Lieske, J. C. and Rissanen, H. and Uitterlinden, A. G. and Raitakari, O. T. and Kiefte-de Jong, J. C. and Dupuis, J. and Rotter, J. I. and North, K. E. and Scott, R. A. and Province, M. A. and Perola, M. and Cupples, L. A. and Turner, S. T. and Sorensen, T. I. A. and Salomaa, V. and Y. Liu and Sung, Y. J. and Qi, L. and Bandinelli, S. and Rich, S. S. and de Mutsert, R. and Tremblay, A. and Oddy, W. H. and Franco, O. H. and Paus, T. and Florez, J. C. and Deloukas, P. and Lyytikainen, L. P. and Chasman, D. I. and Chu, A. Y. and Tanaka, T.}
}
