@article {30965,
	title = {Sediments alleviate the inhibition effects of antibiotics on denitrification: Functional gene, microbial community, and antibiotic resistance gene analysis},
	journal = {Science of the Total EnvironmentScience of the Total Environment},
	volume = {804},
	year = {2022},
	note = {Times Cited: 331879-1026},
	month = {Jan 15},
	abstract = {Both antibiotics and sediments can affect the denitrification in aquatic systems. However, little is known how an-tibiotics influence the denitrification in the presence of sediments. Here, the effects of antibiotics (sulfamethox-azole, tetracycline and ofloxacin) on denitrification in the absence and presence of sediments were investigated. The influencing mechanisms were revealed by quantifying the denitrification functional genes (DNGs), 16S-seq of bacteria, and antibiotic resistance genes (ARGs). The results showed that the presence of antibiotics inhibited NO3-N reduction by decreasing the abundances of narG, nirK, nosZ, total DNGs, and denitrifying bacteria. How-ever, the inhibition effect was alleviated by sediments, which promoted the growth of bacteria and decreased the selective pressure of antibiotics as the vector of bacteria and antibiotics, thus increasing the abundances of denitrifying bacteria and all the DNGs. Partial least-squares path model disclosed that antibiotics had negative ef-fects on bacteria, ARGs and DNGs, while sediments had negative effects on ARGs but positive effects on bacteria and DNGs. The network analysis further revealed the close relation of the genera Bacillus, Acinetobacter, and En-terobacter with the ARGs and DNGs. The findings are helpful to understand the denitrification in antibiotic-polluted natural waters. (C) 2021 Elsevier B.V. All rights reserved.},
	isbn = {0048-9697},
	author = {Zhang, Ruijie and Xuming Xu and Jia, Dantong and Yitao Lyu and Hu, Jingrun and Qian Chen and Sun, Weiling}
}
