Mycosis fungoides is characterized by widespread skin patches that may progress to plaques and tumors, necessitating precise tumor burden assessment for staging and treatment guidance. However, existing methods, including the widely accepted modified Severity Weighted Assessment Tool (mSWAT), present significant challenges in routine practice owing to their time-consuming nature and interobserver variability. This study developed an artificial intelligence model, mSWAT-Net, to estimate mSWAT scores using clinical images of patients with mycosis fungoides. Notably, the overlap area segmentation submodule of mSWAT-Net addressed double-counting errors in multiangle photos through training on 3904 annotated images generated from 61 three-dimensional human images. Across 2463 standardized full-body photographs from 134 imaging series, mSWAT-Net demonstrated performance comparable with that of experienced cutaneous lymphoma specialists, achieving intraclass correlation coefficients of 0.917 (internal validation) and 0.846 (temporal validation) for mSWAT score. Moreover, mSWAT-Net outperformed 3 junior dermatologists in image-based scoring (intraclass correlation coefficient = 0.917 vs 0.777) and demonstrated robust performance when compared with ground truth derived from 3-dimensional patient imaging (intraclass correlation coefficient = 0.812). Finally, mSWAT-Net was deployed as a free web application to support mycosis fungoides management in clinical settings. These findings highlight the potential of mSWAT-Net as an accurate, automated clinical tool for facilitating patient follow-up, treatment monitoring, and remote consultations.
Volatile elements are essential for life development and planetary evolution. However, the timing of their delivery to terrestrial planets remains unclear. Sulfur, selenium, and tellurium are volatiles, but also siderophile elements. Their abundances in Earth’s mantle can be used to determine whether volatile elements were delivered to Earth during or after the segregation of the core. Here, we experimentally measured their partition coefficients between core-forming metal and mantle silicate under pressure, temperature, and oxygen fugacity conditions relevant to a deep magma ocean. Our results show that these elements exhibit similar partitioning behaviors, indicating that core-mantle equilibrium preserves their chondritic relative abundances. If a volatile-rich late veneer has been delivered to Earth after core segregation, it must have been limited in mass, making up a maximum of 0.1% Earth’s mass. This suggests that volatile elements, including water, were accreted continuously during Earth’s growth rather than being delivered predominantly by a late veneer of volatile-rich material such as carbonaceous chondrites.
This longitudinal study investigates the structure, developmental trends, and well-being implications of values among Chinese adolescents – a large, culturally distinctive population undergoing rapid social change. We conducted a large-scale, two-wave longitudinal study (Wave 1: N = 69,115; M = 12.74 ± 2.25 years; 49.84% girls; Wave 2: N = 45,762; M = 12.98 ± 2.22 years; 50.53% girls; with 45,762 students participating in both waves) across a 6-month interval. A three-factor structure of adolescent values emerged: Collective Altruism, Individual Initiative, and Individual Hedonism. Results revealed distinct developmental trajectories: Collective Altruism declined slightly, while Individual Hedonism increased, both stabilizing around mid-adolescence (age~15)—a developmental inflection point in value orientation. Cross-lagged models demonstrated small but significant reciprocal positive associations between Collective Altruism, Individual Initiative, and well-being, while Individual Hedonism showed a small but significant negative association with subsequent well-being. These findings support the theoretical framework of contextually healthy values—value orientations that are culturally normative and developmentally adaptive. This study also provides valuable insights for promoting adolescent mental health and positive development in rapidly modernizing contexts.