科研成果

2011
田君, 唐迅, 余灿清, 陈大方, 陈卿, 曹洋, 范雯怡, 曹卫华, 詹思延, 吕筠, et al. ACE2基因多态性与苯那普利降压效果相关性. 中国公共卫生中国公共卫生. 2011;27:1231-1234.Abstract
目的研究高血压患者血管紧张素转换酶2(ACE2)基因rs2285666和rs2106809位点多态性与服用苯那普利后长期降压效果的关系,探讨ACE2基因与血管紧张素Ⅱ的1型受体(AGTR1)、血管紧张素原(AGT)基因位点之间的交互作用。方法在上海市南市区,选择苯那普利上市后的3年监测研究中单纯服用苯那普利的全部≥35岁高血压患者,共1 447例,分析ACE2基因rs2285666和rs2106809位点多态性与服药后血压变化指标的关联,并应用广义多因子降维法(GMDR)分析ACE2、AGTR1、AGT基因13个位点间的交互作用。结果 1447例高血压患者中,基线血压达标者181例,占12.5%,基线血压未达标者1 266例,占87.5%;成功鉴定rs2285666基因型者1 230例,其中男性746例,女性484例;成功鉴定rs2106809基因型者1 142例,其中男性668例,女性474例;调整年龄、基线血压指标、首诊药物剂量和尿蛋白水平后,基线血压达标者中,rs2285666位点与男性脉压差变化值有关联(β=0.24,P=0.02),rs2106809位点与男性收缩压差值有关联(β=0.23,P=0.04);基线血压未达标者中,rs2106809位点与女性收缩压差值有关联(β=-0.06,P=0.04);交互作用分析结果表明,男性收缩压变化值、女性收缩压差值和女性舒张压差值存在多位点参与的交互作用模型。结论 ACE2基因rs2285666和rs2106809位点与苯那普利的长期降压效果相关,且在降压过程中ACE2、AGTR1、AGT基因间存在交互作用。
Starr DE, Pan D, Newberg JT, Ammann M, Wang EG, Michaelides A, Bluhm H. Acetone adsorption on ice investigated by X-ray spectroscopy and density functional theory. Physical Chemistry Chemical Physics [Internet]. 2011;(44):19988-19996. 访问链接
Ouillette P, Collins R, Shakhan S, Li J, Peres E, Kujawski L, Talpaz M, Kaminski M, Li C, Shedden K, et al. Acquired genomic copy number aberrations and survival in chronic lymphocytic leukemia. [Internet]. 2011;(11):3051-3061. 访问链接
Zhang B, Sun L, Yang Y-M, Huang H-P, Zhu F-P, Wang L, Zhang X-Y, Guo S, Zuo P-L, Zhang CX, et al. Action potential bursts enhance transmitter release at a giant central synapse. Journal of Physiology [Internet]. 2011;(9):2213-2227. 访问链接
Chen H, Sun H, You F, Sun W, Zhou X, Chen L, Yang J, Wang Y, Tang H, Guan Y, et al. Activation of STAT6 by STING is critical for antiviral innate immunity. Cell [Internet]. 2011;(2):436-446. 访问链接
Luo D-G, Yue WWS, Ala-Laurila P, Yau K-W. Activation of visual pigments by light and heat. [Internet]. 2011;(6035):1307-1312. 访问链接
Xu Z, Zhang J, Yang G, Hu M. Acyl peroxy nitrate measurements duringthe photochemical smog season inBeijing, China. Atmospheric Chemistry and Physics Discussions. 2011;11(3):10265-10303.Abstract
In situ measurements of acyl peroxy nitrates (PANs), including peroxyacetyl nitrate (PAN), peroxypropionyl nitrate (PPN), and peroxymethacryloyl nitrate (MPAN), were conducted using a gas chromatography-electron capture detector (GC-ECD) system 5 during the photochemical smog season in Beijing, China. The maximum mixing ratios were 17.81, 2.48, and 0.27 ppbv for PAN, PPN, and MPAN, respectively. During the measurement period, PAN levels twice exceeded the maximum recommended mixing ratio established by the World Health Organization (WHO). Average ratios of PAN/PPN, PAN/MPAN, and PPN/MPAN were 7.41, 47.65, and 6.91, respectively. The average ratio of PAN/O310 (0.15) in Beijing was significantly higher than those in other areasstudied. The frequencies of PANs showed both Gaussian and Weibull modes of distribution. Wind direction was closely related to PAN variation. Anthropogenic sources played an important role in PAN formation, as estimated from PPN and MPAN levels. Relative humidity (RH) and total particle surface area were related with the heteroge- 15 neous reactions of PANs with surface concentrations of particulate matter ≤10 µm in diameter.
Lan G, Schulmeister S, Sourjik V, Tu Y. Adapt locally and act globally: Strategy to maintain high chemoreceptor sensitivity in complex environments. Molecular Systems Biology [Internet]. 2011. 访问链接
Lan G, Schulmeister S, Sourjik V, Tu Y. Adapt locally and act globally: Strategy to maintain high chemoreceptor sensitivity in complex environments. Molecular Systems Biology [Internet]. 2011. 访问链接
Shao S, Lu T, Cai W. Adaptive conservative cell average spectral element methods for transient Wigner equation in quantum transport. Communications in Computational Physics [Internet]. 2011;9(3):711-739. 访问链接Abstract
A new adaptive cell average spectral element method (SEM) is proposed to solve the time-dependent Wigner equation for transport in quantum devices. The proposed cell average SEM allows adaptive non-uniform meshes in phase spaces to reduce the high-dimensional computational cost of Wigner functions while preserving exactly the mass conservation for the numerical solutions. The key feature of the pro- posed method is an analytical relation between the cell averages of the Wigner function in the k-space (local electron density for finite range velocity) and the point values of the distribution, resulting in fast transforms between the local electron density and local fluxes of the discretized Wigner equation via the fast sine and cosine transforms. Numerical results with the proposed method are provided to demonstrate its high accuracy, conservation, convergence and a reduction of the cost using adaptive meshes.
Fassett JT, Hu X, Xu X, Lu Z, Zhang P, Chen Y, Bache RJ. Adenosine kinase regulation of cardiomyocyte hypertrophy. American Journal of Physiology - Heart and Circulatory Physiology [Internet]. 2011;(5):H1722-H1732. 访问链接
Ma J, Michaelides A, Alfè D, Schimka L, Kresse G, Wang E. Adsorption and diffusion of water on graphene from first principles. Physical Review B - Condensed Matter and Materials Physics. 2011;(3).
Cao T, Feng J, Wang EG. Adsorption of hydrogen on the interface of a graphene/boron nitride hybrid atomic membrane. Physical Review B - Condensed Matter and Materials Physics. 2011;(20).
Cao T, Feng J, Wang EG. Adsorption of hydrogen on the interface of a graphene/boron nitride hybrid atomic membrane. Physical Review B [Internet]. 2011;84. 访问链接
Cao T, Feng J, Wang EG. Adsorption of hydrogen on the interface of a graphene/boron nitride hybrid atomic membrane. Physical Review B - Condensed Matter and Materials Physics. 2011;(20).
Wang Y, Zhang L, Ma S, Gao W. Advanced spatial and Temporal Direct Mode for B picture coding, in 2011 IEEE Visual Communications and Image Processing, VCIP 2011, Tainan, Taiwan, November 6-9, 2011.; 2011:1–4. 访问链接
Song B-Y, Zhu W-G. [Advances in effector protein of histone methylation]. Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji [Internet]. 2011;(4):285-292. 访问链接
Zhang Y. Y., Sun Z. D., Yang H. J. The advantages of pre-stack inversion in heterogeneous carbonate reservoir prediction: A case study from Tarim Basin, China, in 73rd EAGE Expanded Abstract.; 2011. 访问链接
Chang RY-W, Leck C, Graus M, Mueller M, Paatero J, Burkhart JF, Stohl A, Orr LH, Hayden K, Li S-M, et al. Aerosol composition and sources in the central Arctic Ocean during ASCOS. ATMOSPHERIC CHEMISTRY AND PHYSICS. 2011;11:10619-10636.Abstract
Measurements of submicron aerosol chemical composition were made over the central Arctic Ocean from 5 August to 8 September 2008 as a part of the Arctic Summer Cloud Ocean Study (ASCOS) using an aerosol mass spectrometer (AMS). The median levels of sulphate and organics for the entire study were 0.051 and 0.055 mu gm(-3), respectively. Positive matrix factorisation was performed on the entire mass spectral time series and this enabled marine biogenic and continental sources of particles to be separated. These factors accounted for 33% and 36% of the sampled ambient aerosol mass, respectively, and they were both predominantly composed of sulphate, with 47% of the sulphate apportioned to marine biogenic sources and 48% to continental sources, by mass. Within the marine biogenic factor, the ratio of methane sulphonate to sulphate was 0.25+/-0.02, consistent with values reported in the literature. The organic component of the continental factor was more oxidised than that of the marine biogenic factor, suggesting that it had a longer photochemical lifetime than the organics in the marine biogenic factor. The remaining ambient aerosol mass was apportioned to an organic-rich factor that could have arisen from a combination of marine and continental sources. In particular, given that the factor does not correlate with common tracers of continental influence, we cannot rule out that the organic factor arises from a primary marine source.
Gordon M, Staebler RM, Liggio J, Vlasenko A, Li S-M, Hayden K. Aerosol flux measurements above a mixed forest at Borden, Ontario. ATMOSPHERIC CHEMISTRY AND PHYSICS. 2011;11:6773-6786.Abstract
Aerosol fluxes were measured above a mixed forest by Eddy Covariance (EC) with a Fast Mobility Particle Sizer (FMPS) at the Borden Forest Research Station in Ontario, Canada between 13 July and 12 August 2009. Chemically speciated flux measurements were made at a height of 29m at the same location between 19 July and 2 August, 2006 using a Quadrupole Aerosol Mass Spectrometer (Q-AMS). The Q-AMS measured an average sulphate deposition velocity of 0.3mms(-1) and an average nitrate deposition velocity of 4.8mms(-1). The FMPS, mounted at a height of 33m (approximately 10m above the canopy top) and housed in a temperature controlled enclosure, measured size-resolved particle concentrations from 3 to 410 nm diameter at a rate of 1 Hz. For the size range 18 < D < 452 nm, 60% of fluxes were upward. The exchange velocity was between -0.5 and 2.0 mms(-1), with median values near 0.5 mms(-1) for all sizes between 22 and 310 nm. The size distribution of the apparent production rate of particles at 33m peaked at a diameter of 75 nm. Results indicate a decoupling of the above and below canopy spaces, whereby particles are stored in the canopy space at night, and are then diluted with cleaner air above during the day.

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