科研成果

1999
Ma X, Wang E, Zhou W, Jefferson DA, Chen J, Deng S, Xu N, Yuan J. Polymerized carbon nanobells and their field-emission properties. Applied Physics Letters. 1999;(20):3105-3107.
Gu B-L, Gui H, Liu Z-R, Zhang X-W. Possible order-disorder phase diagrams in (A′xA″1 - X)BO3 and A(B′xB″1 - x)O3 complex perovskites. Journal of Applied Physics. 1999;(4):2408-2413.
Liu ZR, Chen ZM, Shao KS, Li JL. Preliminary laboratory simulation on the atmospheric activity of β-pinene with ozone. Environmental Chemistry-China. 1999;18(1):28-33.
Tehrani S, Slaughter JM, Chen E, Durlam M, Shi J, DeHerrera M. Progress and outlook for MRAM technology. Digests of the Intermag Conference. 1999:GA-02.
Tehrani S, Slaughter JM, Chen E, Durlam M, Shi J, DeHerrera M. Progress and outlook for mram technology. IEEE Transactions on Magnetics. 1999;(5 PART 1):2814-2819.
Li W-Z, Wang R-X, Lin D-W, Mao F-L, Han Y-Z, Lai L-H. Progress of bioinformatics database services. Progress in Biochemistry and Biophysics. 1999;(1):25-26.
Hu X, Cao S, Loh HH, Wei L-N. Promoter activity of mouse κ opioid receptor gene in transgenic mouse. Molecular Brain Research [Internet]. 1999;(1):35-43. 访问链接
Li W, Liu Z, Lai L. Protein loops on structurally similar scaffolds: Database and conformational analysis. Biopolymers [Internet]. 1999;(6):481-495. 访问链接
Li W, Liu Z, Liang S, Han Y, Lai L. Rational screenning in combinatorial peptide libraries of protein functional loop. Chinese Science Bulletin. 1999;(23):2150-2154.
Xiao R-P, Cheng H, Zhou Y-Y, Kuschel M, Lakatta EG. Recent advances in cardiac β2-adrenergic signal transduction. Circulation Research [Internet]. 1999;(11):1092-1100. 访问链接
Xiao R-P, Cheng H, Zhou Y-Y, Kuschel M, Lakatta EG. Recent advances in cardiac β2-adrenergic signal transduction. Circulation Research [Internet]. 1999;(11):1092-1100. 访问链接
Yu Z, Chen M, Nie L, Lu H, Ming X, Zheng H, Qu L-J, Chen Z. Recovery of transgenic orchid plants with hygromycin selection by particle bombardment to protocorms. Plant Cell, Tissue and Organ Culture. 1999;(2):87-92.
Li N, Qu L-J, Liu Y, Li Q, Gu H, Chen Z. The refolding, purification, and activity analysis of a rice Bowman-Birk inhibitor expressed in Escherichia coli. Protein Expression and Purification [Internet]. 1999;(1):99-104. 访问链接
Xiong J-W, Leahy A, Stuhlmann H. Retroviral promoter-trap insertion into a novel mammalian septin gene expressed during mouse neuronal development. Mechanisms of Development [Internet]. 1999;(1-2):183-191. 访问链接
Xu J-H, Zeng X-H, He L-M, Qu A-L, Zhou Z. Role of M-type receptor in internal calcium release and quantal secretion in rat adrenal chromaffin cells. Acta Physiologica Sinica [Internet]. 1999;(5):564-570. 访问链接
Volk R, Schwartz JJ, Li J, Rosenberg RD, Simons M. The role of syndecan cytoplasmic domain in basic fibroblast growth factor-dependent signal transduction. Journal of Biological Chemistry [Internet]. 1999;(34):24417-24424. 访问链接
Métais C, Li J, Li J, Simons M, Sellke FW. Serotonin-induced coronary contraction increases after blood cardioplegia-reperfusion: Role of COX-2 expression. Circulation [Internet]. 1999;(19 SUPPL.):II328-II334. 访问链接
Tsymbal EY, Pettifor DG, Shi J, Salamon MB. Sign of thermoelectric power in Co/Cu and Fe/Cr multilayers. Physical Review B - Condensed Matter and Materials Physics. 1999;(13):8371-8374.
Zhu AJ, Haase I, Watt FM. Signaling via β1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro. [Internet]. 1999;(12):6728-6733. 访问链接
Mohamed SS*, Khalid SA, Ward SA, Wan TSM, Tang HPO, Zheng M*, Haynes RK, Edwards G. Simultaneous determination of artemether and its major metabolite dihydroartemisinin in plasma by gas chromatography–mass spectrometry-selected ion monitoring. Journal of Chromatography B: Biomedical Sciences and Applications [Internet]. 1999;731:251 - 260. LINKAbstract
A sensitive, selective, and reproducible GC–MS–SIM method was developed for determination of artemether (ARM) and dihydroartemisinin (DHA) in plasma using artemisinin (ART) as internal standard. Solid phase extraction was performed using C18 Bond Elut cartridges. The analysis was carried out using a HP-5MS 5% phenylmethylsiloxane capillary column. The recoveries of ARM, DHA and ART were 94.9±1.6%, 92.2±4.1% and 81.3±1.2%, respectively. The limit of quantification in plasma was 5 ng/ml (C.V.≤17.4% for ARM and 15.2% for DHA). Calibration curves were linear with R2≥0.988. Within day coefficients of variation were 3–10.4% for ARM and 7.7–14.5% for DHA. Between day coefficients of variations were 6.5–15.4% and 7.6–14.1% for ARM and DHA. The method is currently being used for pharmacokinetic studies. Preliminary data on pharmacokinetics showed Cmax of 245.2 and 35.6 ng/ml reached at 2 and 3 h and AUC0–8h of 2463.6 and 111.8 ngh/ml for ARM and DHA, respectively.

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