科研成果

2014
Wang H, Xu X, Fassett J, Kwak D, Liu X, Hu X, Falls TJ, Bell JC, Li H, Bitterman P, et al. Double-stranded RNA-dependent protein kinase deficiency protects the heart from systolic overload-induced congestive heart failure. Circulation [Internet]. 2014;(13):1397-1406. 访问链接 SCI被引用次数:34.
Lu Z, Xu X, Fassett J, Kwak D, Liu X, Hu X, Wang H, Guo H, Xu D, Yan S, et al. Loss of the eukaryotic initiation factor 2α kinase general control nonderepressible 2 protects mice from pressure overload-induced congestive heart failure without affecting ventricular hypertrophy. Hypertension [Internet]. 2014;(1):128-135. 访问链接 SCI被引用次数:32.
Xu X, Lu Z, Fassett J, Zhang P, Hu X, Liu X, Kwak D, Li J, Zhu G, Tao Y, et al. Metformin protects against systolic overload-induced heart failure independent of AMP-activated protein kinase α2. Hypertension [Internet]. 2014;(4):723-728. 访问链接 SCI被引用次数:55.
2013
Zhang P, Xu X, Hu X, Wang H, Fassett J, Huo Y, Chen Y, Bache RJ. DDAH1 deficiency attenuates endothelial cell cycle progression and angiogenesis. PLoS ONE [Internet]. 2013;(11). 访问链接 SCI被引用次数:16.
Fassett JT, Hu X, Xu X, Lu Z, Zhang P, Chen Y, Bache RJ. AMPK attenuates microtubule proliferation in cardiac hypertrophy. American Journal of Physiology - Heart and Circulatory Physiology [Internet]. 2013;(5):H749-H758. 访问链接 SCI被引用次数:35.
Fassett JT, Xu X, Kwak D, Wang H, Liu X, Hu X, Bache RJ, Chen Y. Microtubule Actin Cross-Linking Factor 1 Regulates Cardiomyocyte Microtubule Distribution and Adaptation to Hemodynamic Overload. PLoS ONE [Internet]. 2013;(9). 访问链接 SCI被引用次数:39.
2012
Chen Y, Guo H, Xu D, Xu X, Wang H, Hu X, Lu Z, Kwak D, Xu Y, Gunther R, et al. Left ventricular failure produces profound lung remodeling and pulmonary hypertension in mice: Heart failure causes severe lung disease. Hypertension [Internet]. 2012;(6):1170-1178. 访问链接 SCI被引用次数:87.
2011
Fassett JT, Hu X, Xu X, Lu Z, Zhang P, Chen Y, Bache RJ. Adenosine kinase regulation of cardiomyocyte hypertrophy. American Journal of Physiology - Heart and Circulatory Physiology [Internet]. 2011;(5):H1722-H1732. 访问链接 SCI被引用次数:15.
Hu X, Xu X, Lu Z, Zhang P, Fassett J, Zhang Y, Xin Y, Hall JL, Viollet B, Bache RJ, et al. AMP activated protein kinase-α2 regulates expression of estrogen-related receptor-α, a metabolic transcription factor related to heart failure development. Hypertension [Internet]. 2011;(4):696-703. 访问链接 SCI被引用次数:62.
Zhang P, Hu X, Xu X, Chen Y, Bache RJ. Dimethylarginine dimethylaminohydrolase 1 modulates endothelial cell growth through nitric oxide and Akt. Arteriosclerosis, Thrombosis, and Vascular Biology [Internet]. 2011;(4):890-897. 访问链接 SCI被引用次数:31.
Hu X, Atzler D, Xu X, Zhang P, Guo H, Lu Z, Fassett J, Schwedhelm E, Böger RH, Bache RJ, et al. Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine. Arteriosclerosis, Thrombosis, and Vascular Biology [Internet]. 2011;(7):1540-1546. 访问链接 SCI被引用次数:85.
Xu D, Guo H, Xu X, Lu Z, Fassett J, Hu X, Xu Y, Tang Q, Hu D, Somani A, et al. Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase. Hypertension [Internet]. 2011;(2):303-309. 访问链接 SCI被引用次数:53.
2010
Lu Z, Xu X, Hu X, Lee S, Traverse JH, Zhu G, Fassett J, Tao Y, Zhang P, Remedios CD, et al. Oxidative stress regulates left ventricular PDE5 expression in the failing heart. Circulation [Internet]. 2010;(13):1474-1483. 访问链接 SCI被引用次数:128.
Lu Z, Xu X, Hu X, Fassett J, Zhu G, Tao Y, Li J, Huang Y, Zhang P, Zhao B, et al. PGC-1α regulates expression of myocardial mitochondrial antioxidants and myocardial oxidative stress after chronic systolic overload. Antioxidants and Redox Signaling [Internet]. 2010;(7):1011-1022. 访问链接 SCI被引用次数:167.
2009
Fassett JT, Xu X, Hu X, Zhu G, French J, Chen Y, Bache RJ. Adenosine regulation of microtubule dynamics in cardiac hypertrophy. American Journal of Physiology - Heart and Circulatory Physiology [Internet]. 2009;(2):H523-H532. 访问链接 SCI被引用次数:21.
Hu X, Xu X, Zhu G, Atzler D, Kimoto M, Chen J, Schwedhelm E, Lüneburg N, Böger RH, Zhang P, et al. Vascular endothelial-specific dimethylarginine dimethylaminohydrolase-1- deficient mice reveal that vascular endothelium plays an important role in removing asymmetric dimethylarginine. Circulation [Internet]. 2009;(22):2222-2229. 访问链接 SCI被引用次数:63.
2008
Lu Z, Fassett J, Xu X, Hu X, Zhu G, French J, Zhang P, Schnermann J, Bache RJ, Chen Y. Adenosine A3 receptor deficiency exerts unanticipated protective effects on the pressure-overloaded left ventricle. Circulation [Internet]. 2008;(17):1713-1721. 访问链接 SCI被引用次数:35.
Zhang P, Hu X, Xu X, Fassett J, Zhu G, Viollet B, Xu W, Wiczer B, Bernlohr DA, Bache RJ, et al. AMP activated protein kinase-α2 deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction in mice. Hypertension [Internet]. 2008;(5):918-924. 访问链接 SCI被引用次数:144.
Hu X, Xu X, Huang Y, Fassett J, Flagg TP, Zhang Y, Nichols CG, Bache RJ, Chen Y. Disruption of sarcolemmal atp-sensitive potassium channel activity impairs the cardiac response to systolic overload. Circulation Research [Internet]. 2008;(9):1009-1017. 访问链接
Xu X, Fassett J, Hu X, Zhu G, Lu Z, Li Y, Schnermann J, Bache RJ, Chen Y. Ecto-5′ -nucleotidase deficiency exacerbates pressure-overload- induced left ventricular hypertrophy and dysfunction. Hypertension [Internet]. 2008;(6):1557-1564. 访问链接 SCI被引用次数:35.

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