<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Li, Ran</style></author><author><style face="normal" font="default" size="100%">Xinghua* Qiu</style></author><author><style face="normal" font="default" size="100%">Qiaoyun Yang</style></author><author><style face="normal" font="default" size="100%">Li, Keqiu</style></author><author><style face="normal" font="default" size="100%">Li, Guang</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">MiR-125a-5p is Upregulated in Plasma of Residents from An Electronic Waste Recycling Site</style></title><secondary-title><style face="normal" font="default" size="100%">Asian Journal of Ecotoxicology</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Apr</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">2</style></number><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">134-143</style></pages><isbn><style face="normal" font="default" size="100%">1673-5897</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">The mechanism of health effects caused by organohalogen pollutants, e.g., toxins from electronic waste (e-waste), is poorly understood. We supposed that microRNAs (miRNAs), an important post-transcriptional regulator, could play a role in this process. In this study, fasting peripheral blood samples were collected from residents living at an e-waste site in northern China and a nearby reference population. Concentrations of e-waste related organohalogen pollutants in plasma from the exposure group were higher than the corresponding measurement in the reference group. Correspondingly, sixty miRNAs in plasma showed &amp;gt; 2-fold change between the two groups in microarray analysis. Among them, miR-125a-5p was confirmed to be upregulated by qRT-PCR and its validated targets were enriched in responses to xenobiotics and cancer related pathways. Furthermore, significant positive conelations were found between levels of miR-125a-5p in plasma and reactive oxygen species (ROS) in polymorphonuclear neutrophil leukocytes (P &amp;lt; 0.05). These evidences suggested oxidative stress might be an intermediate between e-waste related POPs exposure and alteration of plasma miRNA.</style></abstract><accession-num><style face="normal" font="default" size="100%">BIOSIS:PREV201700046021</style></accession-num><notes><style face="normal" font="default" size="100%">&lt;p&gt;Times Cited: 01&lt;/p&gt;</style></notes></record></records></xml>