@article {15093,
	title = {Polycyclic aromatic hydrocarbon (PAH) exposure and oxidative stress for a rural population from the North China Plain},
	journal = {Environmental Science and Pollution Research},
	volume = {22},
	number = {3},
	year = {2015},
	note = {Times Cited: 111st International Conference on Environmental Specimen BankOct, 2013Shanghai, PEOPLES R CHINAState Key Lab Pollut Control \&amp; Resource Reuse; Minist Educ, Key Lab Yangtze River Water Environm122351614-7499},
	month = {Feb},
	pages = {1760-1769},
	abstract = {Polycyclic aromatic hydrocarbons (PAHs) belong to a class of ubiquitous pollutants and are possibly associated with adverse health effects. In this study, we aimed to assess PAH exposure by measuring the hydroxylated metabolites (hydroxy-PAHs) in urine samples of a rural population from the North China Plain and to explore the possible associations between PAH exposure and oxidative stress indicated by urinary malondialdehyde (MDA) and 8-hydroxy-2{\textquoteright}-deoxyguanosine (8-OHdG). High levels of urinary hydroxy-PAHs were observed, with the geometric mean concentrations of 0.57, 2.2, 5.0, 7.0, and 16.6 mu g g(-1) creatinine for 1-hydroxypyrene, hydroxyphenanthrenes, hydroxyfluorenes, hydroxybiphenyls, and hydroxynaphthalenes, respectively. Particularly in the winter season, the exposures were 2.3-6.0-fold of those in the spring. Corresponding to PAH exposure, levels of urinary MDA were positively associated with hydroxy-PAHs after controlling for confounders in the linear regression models (p \&lt; 0.05). An estimation indicated 21.3-39.3 \% increment of urinary MDA per one-fold increase of hydroxy-PAHs. In contrast, no significant correlation was found between urinary 8-OHdG and hydroxy-PAHs; alternatively, living at the e-waste recycling site was found a significant factor on this oxidative DNA damage. These results provide evidence on high PAH exposure and the induction of oxidative stress on lipid peroxidation for this rural population.},
	isbn = {0944-1344},
	author = {Qiaoyun Yang and Xinghua Qiu and Li, Ran and Jin Ma and Li, Keqiu and Li, Guang}
}
