<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bingqing Xie</style></author><author><style face="normal" font="default" size="100%">Da Sun</style></author><author><style face="normal" font="default" size="100%">Yuanyuan Du</style></author><author><style face="normal" font="default" size="100%">Jun Jia</style></author><author><style face="normal" font="default" size="100%">Shicheng Sun</style></author><author><style face="normal" font="default" size="100%">Jun Xu</style></author><author><style face="normal" font="default" size="100%">Yifang Liu</style></author><author><style face="normal" font="default" size="100%">Chengang Xiang</style></author><author><style face="normal" font="default" size="100%">Sitong Chen</style></author><author><style face="normal" font="default" size="100%">Huangfan Xie</style></author><author><style face="normal" font="default" size="100%">Qiming Wang</style></author><author><style face="normal" font="default" size="100%">Guangya Li</style></author><author><style face="normal" font="default" size="100%">Xuehui Lyu</style></author><author><style face="normal" font="default" size="100%">Hui Shen</style></author><author><style face="normal" font="default" size="100%">Shiyu Li</style></author><author><style face="normal" font="default" size="100%">Min Wu</style></author><author><style face="normal" font="default" size="100%">Xiaonan Zhang</style></author><author><style face="normal" font="default" size="100%">Yue Pu</style></author><author><style face="normal" font="default" size="100%">Kuanhui Xiang</style></author><author><style face="normal" font="default" size="100%">Weifeng Lai</style></author><author><style face="normal" font="default" size="100%">Peng Du</style></author><author><style face="normal" font="default" size="100%">Zhenghong Yuan</style></author><author><style face="normal" font="default" size="100%">Cheng Li</style></author><author><style face="normal" font="default" size="100%">Cheng Li</style></author><author><style face="normal" font="default" size="100%">Shichun Lu</style></author><author><style face="normal" font="default" size="100%">Hongkui Deng</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts</style></title><secondary-title><style face="normal" font="default" size="100%">Cell Res </style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2019</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://pubmed.ncbi.nlm.nih.gov/31270412/</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">29</style></volume><pages><style face="normal" font="default" size="100%">696-670</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Terminally differentiated cells can be generated by lineage reprogramming, which is, however, hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy by mimicking the natural regeneration route, which permits generating expandable hepatic progenitor cells and functionally competent human hepatocytes. Fibroblasts were first induced into human hepatic progenitor-like cells (hHPLCs), which could robustly expand in vitro and efficiently engraft in vivo. Moreover, hHPLCs could be efficiently induced into mature human hepatocytes (hiHeps) in vitro, whose molecular identity highly resembles primary human hepatocytes (PHHs). Most importantly, hiHeps could be generated in large quantity and were functionally competent to replace PHHs for drug-metabolism estimation, toxicity prediction and hepatitis B virus infection modeling. Our results highlight the advantages of the progenitor stage for successful lineage reprogramming. This strategy is promising for generating other mature human cell types by lineage reprogramming.</style></abstract><issue><style face="normal" font="default" size="100%">9</style></issue></record></records></xml>