<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Grady, S. T.</style></author><author><style face="normal" font="default" size="100%">Koutrakis, P.</style></author><author><style face="normal" font="default" size="100%">Hart, J. E.</style></author><author><style face="normal" font="default" size="100%">Coull, B. A.</style></author><author><style face="normal" font="default" size="100%">Schwartz, J.</style></author><author><style face="normal" font="default" size="100%">Laden, F.</style></author><author><style face="normal" font="default" size="100%">J.J. Zhang</style></author><author><style face="normal" font="default" size="100%">Gong, J.</style></author><author><style face="normal" font="default" size="100%">Moy, M. L.</style></author><author><style face="normal" font="default" size="100%">Garshick, E.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Indoor black carbon of outdoor origin and oxidative stress biomarkers in patients with chronic obstructive pulmonary disease</style></title><secondary-title><style face="normal" font="default" size="100%">Environment International</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Environ Int</style></alt-title><short-title><style face="normal" font="default" size="100%">Environ IntEnviron Int</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">copd</style></keyword><keyword><style  face="normal" font="default" size="100%">pollution</style></keyword><keyword><style  face="normal" font="default" size="100%">Urinary oxidative stress</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jun</style></date></pub-dates></dates><edition><style face="normal" font="default" size="100%">2018/03/27</style></edition><volume><style face="normal" font="default" size="100%">115</style></volume><pages><style face="normal" font="default" size="100%">188-195</style></pages><isbn><style face="normal" font="default" size="100%">1873-6750 (Electronic)0160-4120 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">English</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;OBJECTIVES: We assessed relationships between indoor black carbon (BC) exposure and urinary oxidative stress biomarkers, 8-hydroxy-2'-deoxyguanosine (8-OHdG) and malondialdehyde (MDA), in participants with chronic obstructive pulmonary disease (COPD). METHODS: Eighty-two participants completed in-home air sampling for one week prior to providing urine samples up to four times in a year. Weekly indoor and daily outdoor concentrations were used to estimate indoor daily lags and moving averages. There were no reported in-home BC sources, thus indoor levels closely represented outdoor BC infiltration. Mixed effects regression models with a random intercept for each participant were used to assess relationships between indoor BC and 8-OHdG and MDA, adjusting for age, race, BMI, diabetes, heart disease, season, time of urine collection, urine creatinine, and outdoor humidity and temperature. RESULTS: There were positive effects of BC on 8-OHdG and MDA, with the greatest effect the day before urine collection (6.9% increase; 95% CI 0.9-13.3%, per interquartile range: 0.22mug/m(3)) for 8-OHdG and 1 to 4days before collection (8.3% increase; 95% CI 0.03-17.3% per IQR) for MDA. Results were similar in models adjusting for PM2.5 not associated with BC and NO2 (10.4% increase, 95% CI: 3.5-17.9 for 8-OHdG; 8.1% increase, 95% CI: -1.1-18.1 for MDA). Effects on 8-OHdG were greater in obese participants. CONCLUSIONS: We found positive associations between BC exposure and 8-OHdG and MDA, in which associations with 8-OHdG were stronger in obese participants. These results suggest that exposure to low levels of traffic-related pollution results in lipid peroxidation and oxidative DNA damage in individuals with COPD.&lt;/p&gt;</style></abstract><accession-num><style face="normal" font="default" size="100%">29574339</style></accession-num><notes><style face="normal" font="default" size="100%">&lt;p&gt;Grady, Stephanie TKoutrakis, PetrosHart, Jaime ECoull, Brent ASchwartz, JoelLaden, FrancineZhang, Junfeng JimGong, JichengMoy, Marilyn LGarshick, EricengR01 ES019853/ES/NIEHS NIH HHS/NetherlandsEnviron Int. 2018 Jun;115:188-195. doi: 10.1016/j.envint.2018.02.040. Epub 2018 Mar 22.&lt;/p&gt;</style></notes><custom2><style face="normal" font="default" size="100%">PMC5970068</style></custom2><auth-address><style face="normal" font="default" size="100%">Research and Development Service, VA Boston Healthcare System, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: stephanie.grady@channing.harvard.edu.Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.Nicholas School of the Environment, Duke University, Durham, NC, USA.Nicholas School of the Environment, Duke University, Durham, NC, USA; BIC-ESAT and SKL-ESPC, College of Environmental Sciences and Engineering, Peking University, Beijing, China.Pulmonary, Allergy, Sleep, and Critical Care Medicine, VA Boston Healthcare System and Harvard Medical School, Boston, MA, USA.Pulmonary, Allergy, Sleep, and Critical Care Medicine, VA Boston Healthcare System and Harvard Medical School, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.</style></auth-address></record></records></xml>