<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bhatti, P.</style></author><author><style face="normal" font="default" size="100%">Mirick, D. K.</style></author><author><style face="normal" font="default" size="100%">Randolph, T. W.</style></author><author><style face="normal" font="default" size="100%">Gong, J.</style></author><author><style face="normal" font="default" size="100%">Buchanan, D. T.</style></author><author><style face="normal" font="default" size="100%">J.J. Zhang</style></author><author><style face="normal" font="default" size="100%">Davis, S.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Oxidative DNA damage during night shift work</style></title><secondary-title><style face="normal" font="default" size="100%">Occup Environ Med</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Occup Environ MedOccup Environ Med</style></alt-title><short-title><style face="normal" font="default" size="100%">Occup Environ Med</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">*DNA Damage</style></keyword><keyword><style  face="normal" font="default" size="100%">*DNA Repair</style></keyword><keyword><style  face="normal" font="default" size="100%">*oxidative DNA damage</style></keyword><keyword><style  face="normal" font="default" size="100%">*Oxidative Stress</style></keyword><keyword><style  face="normal" font="default" size="100%">*shift work</style></keyword><keyword><style  face="normal" font="default" size="100%">*Work Schedule Tolerance</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Circadian Rhythm</style></keyword><keyword><style  face="normal" font="default" size="100%">Cross-Sectional Studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Deoxyguanosine/*analogs &amp; derivatives/urine</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Melatonin/*urine</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidation-Reduction</style></keyword><keyword><style  face="normal" font="default" size="100%">Sleep</style></keyword><keyword><style  face="normal" font="default" size="100%">Work</style></keyword><keyword><style  face="normal" font="default" size="100%">Young Adult</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Sep</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">9</style></number><edition><style face="normal" font="default" size="100%">2017/06/28</style></edition><volume><style face="normal" font="default" size="100%">74</style></volume><pages><style face="normal" font="default" size="100%">680-683</style></pages><isbn><style face="normal" font="default" size="100%">1470-7926 (Electronic)1351-0711 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">English</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;OBJECTIVES: We previously reported that compared with night sleep, day sleep among shift workers was associated with reduced urinary excretion of 8-hydroxydeoxyguanosine (8-OH-dG), potentially reflecting a reduced ability to repair 8-OH-dG lesions in DNA. We identified the absence of melatonin during day sleep as the likely causative factor. We now investigate whether night work is also associated with reduced urinary excretion of 8-OH-dG. METHODS: For this cross-sectional study, 50 shift workers with the largest negative differences in night work versus night sleep circulating melatonin levels (measured as 6-sulfatoxymelatonin in urine) were selected from among the 223 shift workers included in our previous study. 8-OH-dG concentrations were measured in stored urine samples using high performance liquid chromatography with electrochemical detection. Mixed effects models were used to compare night work versus night sleep 8-OH-dG levels. RESULTS: Circulating melatonin levels during night work (mean=17.1 ng/mg creatinine/mg creatinine) were much lower than during night sleep (mean=51.7 ng/mg creatinine). In adjusted analyses, average urinary 8-OH-dG levels during the night work period were only 20% of those observed during the night sleep period (95% CI 10% to 30%; p&amp;lt;0.001). CONCLUSIONS: This study suggests that night work, relative to night sleep, is associated with reduced repair of 8-OH-dG lesions in DNA and that the effect is likely driven by melatonin suppression occurring during night work relative to night sleep. If confirmed, future studies should evaluate melatonin supplementation as a means to restore oxidative DNA damage repair capacity among shift workers.&lt;/p&gt;</style></abstract><accession-num><style face="normal" font="default" size="100%">28652381</style></accession-num><notes><style face="normal" font="default" size="100%">&lt;p&gt;Bhatti, ParveenMirick, Dana KRandolph, Timothy WGong, JichengBuchanan, Diana TaibiZhang, Junfeng JimDavis, ScottengR01 CA097090/CA/NCI NIH HHS/R01 CA116400/CA/NCI NIH HHS/Research Support, Non-U.S. Gov'tResearch Support, N.I.H., ExtramuralEnglandOccup Environ Med. 2017 Sep;74(9):680-683. doi: 10.1136/oemed-2017-104414. Epub 2017 Jun 26.&lt;/p&gt;</style></notes><auth-address><style face="normal" font="default" size="100%">Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.Program in Biostatistics and Biomathematics, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.Duke University, Nicholas School of the Environment and Duke Global Health Institute, Durham, North Carolina, USA.Department of Environmental Science, College of Environmental Sciences and Engineering &amp; BIC-ESAT, Peking University, Beijing, China.Biobehavioral Nursing and Health Systems, School of Nursing, University of Washington, Seattle, Washington, USA.</style></auth-address></record></records></xml>