<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Huang, W.</style></author><author><style face="normal" font="default" size="100%">Wang, G. F.</style></author><author><style face="normal" font="default" size="100%">Lu, S. E.</style></author><author><style face="normal" font="default" size="100%">Kipen, H.</style></author><author><style face="normal" font="default" size="100%">Y.D. Wang</style></author><author><style face="normal" font="default" size="100%">Hu, M.</style></author><author><style face="normal" font="default" size="100%">Lin, W. W.</style></author><author><style face="normal" font="default" size="100%">Rich, D.</style></author><author><style face="normal" font="default" size="100%">Ohman-Strickland, P.</style></author><author><style face="normal" font="default" size="100%">Diehl, S. R.</style></author><author><style face="normal" font="default" size="100%">Zhu, P.</style></author><author><style face="normal" font="default" size="100%">Tong, J.</style></author><author><style face="normal" font="default" size="100%">Gong, J. C.</style></author><author><style face="normal" font="default" size="100%">T. Zhu</style></author><author><style face="normal" font="default" size="100%">Zhang, J. F.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inflammatory and Oxidative Stress Responses of Healthy Young Adults to Changes in Air Quality during the Beijing Olympics</style></title><secondary-title><style face="normal" font="default" size="100%">American Journal of Respiratory and Critical Care Medicine</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Am J Resp Crit Care</style></alt-title><short-title><style face="normal" font="default" size="100%">Am J Resp Crit CareAm J Resp Crit Care</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">air pollution</style></keyword><keyword><style  face="normal" font="default" size="100%">ambient air</style></keyword><keyword><style  face="normal" font="default" size="100%">asthmatic-children</style></keyword><keyword><style  face="normal" font="default" size="100%">coronary-artery-disease</style></keyword><keyword><style  face="normal" font="default" size="100%">DNA-damage</style></keyword><keyword><style  face="normal" font="default" size="100%">exhaled breath condensate</style></keyword><keyword><style  face="normal" font="default" size="100%">heart-disease</style></keyword><keyword><style  face="normal" font="default" size="100%">inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">nitric-oxide</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative Stress</style></keyword><keyword><style  face="normal" font="default" size="100%">particulate matter</style></keyword><keyword><style  face="normal" font="default" size="100%">pm2.5 exposure</style></keyword><keyword><style  face="normal" font="default" size="100%">pollution</style></keyword><keyword><style  face="normal" font="default" size="100%">respiratory health</style></keyword><keyword><style  face="normal" font="default" size="100%">the beijing olympics</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Dec 1</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">11</style></number><volume><style face="normal" font="default" size="100%">186</style></volume><pages><style face="normal" font="default" size="100%">1150-1159</style></pages><isbn><style face="normal" font="default" size="100%">1073-449x</style></isbn><language><style face="normal" font="default" size="100%">English</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Rationale: Unprecedented pollution control actions during the Beijing Olympics provided a quasi-experimental opportunity to examine biologic responses to drastic changes in air pollution levels.Objectives: To determine whether changes in levels of biomarkers reflecting pulmonary inflammation and pulmonary and systemic oxidative stress were associated with changes in air pollution levels in healthy young adults.Methods: We measured fractional exhaled nitric oxide, a number of exhaled breath condensate markers (H+, nitrite, nitrate, and 8-isoprostane), and urinary 8-hydroxy-2-deoxyguanosine in 125 participants twice in each of the pre- (high pollution), during(low pollution), and post-Olympic (high pollution) periods. We measured concentrations of air pollutants near where the participants lived and worked. We used mixed-effects models to estimate changes in biomarker levels across the three periods and to examine whether changes in biomarker levels were associated with changes in pollutant concentrations, adjusting for meteorologic parameters.Measurements and Main Results: From the pre- to the during-Olympic period, we observed significant and often large decreases (ranging from -4.5% to -72.5%) in levels of all the biomarkers. From the during-Olympic to the post-Olympic period, we observed significant and larger increases (48-360%) in levels of these same biomarkers. Moreover, increased pollutant concentrations were consistently associated with statistically significant increases in biomarker levels.Conclusions: These findings support the important role of oxidative stress and that of pulmonary inflammation in mediating air pollution health effects. The findings demonstrate the utility of novel and noninvasive biomarkers in the general population consisting largely of healthy individuals.&lt;/p&gt;</style></abstract><accession-num><style face="normal" font="default" size="100%">WOS:000312040600020</style></accession-num><notes><style face="normal" font="default" size="100%">&lt;p&gt;050ggTimes Cited:69Cited References Count:61&lt;/p&gt;</style></notes><auth-address><style face="normal" font="default" size="100%">Peking Univ, Coll Environm Sci &amp; Engn, Beijing 100871, Peoples R ChinaPeking Univ, Ctr Environm &amp; Hlth, Beijing 100871, Peoples R ChinaPeking Univ, Hosp 1, Dept Pulm Med, Beijing 100871, Peoples R ChinaPeking Univ, Hosp 1, Dept Hematol, Beijing 100871, Peoples R ChinaUniv Med &amp; Dent New Jersey, Robert Wood Johnson Med Sch, Dept Environm &amp; Occupat Med, Piscataway, NJ 08854 USAUniv Med &amp; Dent New Jersey, Robert Wood Johnson Med Sch, Environm &amp; Occupat Hlth Sci Inst, Piscataway, NJ 08854 USAUniv Med &amp; Dent New Jersey, Sch Publ Hlth, Dept Biostat, Piscataway, NJ 08854 USAUniv Med &amp; Dent New Jersey, Sch Publ Hlth, Dept Environm Hlth, Piscataway, NJ 08854 USAUniv Med &amp; Dent New Jersey, Sch Dent, Ctr Pharmacogen &amp; Complex Dis, Piscataway, NJ 08854 USAPeking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100871, Peoples R ChinaUniv Rochester, Sch Med &amp; Dent, Dept Community &amp; Prevent Med, Rochester, NY USAUniv So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA</style></auth-address></record></records></xml>