@article {18203,
	title = {Indoor black carbon of outdoor origin and oxidative stress biomarkers in patients with chronic obstructive pulmonary disease},
	journal = {Environment International},
	volume = {115},
	year = {2018},
	note = {Grady, Stephanie TKoutrakis, PetrosHart, Jaime ECoull, Brent ASchwartz, JoelLaden, FrancineZhang, Junfeng JimGong, JichengMoy, Marilyn LGarshick, EricengR01 ES019853/ES/NIEHS NIH HHS/NetherlandsEnviron Int. 2018 Jun;115:188-195. doi: 10.1016/j.envint.2018.02.040. Epub 2018 Mar 22.},
	month = {Jun},
	pages = {188-195},
	edition = {2018/03/27},
	abstract = {OBJECTIVES: We assessed relationships between indoor black carbon (BC) exposure and urinary oxidative stress biomarkers, 8-hydroxy-2{\textquoteright}-deoxyguanosine (8-OHdG) and malondialdehyde (MDA), in participants with chronic obstructive pulmonary disease (COPD). METHODS: Eighty-two participants completed in-home air sampling for one week prior to providing urine samples up to four times in a year. Weekly indoor and daily outdoor concentrations were used to estimate indoor daily lags and moving averages. There were no reported in-home BC sources, thus indoor levels closely represented outdoor BC infiltration. Mixed effects regression models with a random intercept for each participant were used to assess relationships between indoor BC and 8-OHdG and MDA, adjusting for age, race, BMI, diabetes, heart disease, season, time of urine collection, urine creatinine, and outdoor humidity and temperature. RESULTS: There were positive effects of BC on 8-OHdG and MDA, with the greatest effect the day before urine collection (6.9\% increase; 95\% CI 0.9-13.3\%, per interquartile range: 0.22mug/m(3)) for 8-OHdG and 1 to 4days before collection (8.3\% increase; 95\% CI 0.03-17.3\% per IQR) for MDA. Results were similar in models adjusting for PM2.5 not associated with BC and NO2 (10.4\% increase, 95\% CI: 3.5-17.9 for 8-OHdG; 8.1\% increase, 95\% CI: -1.1-18.1 for MDA). Effects on 8-OHdG were greater in obese participants. CONCLUSIONS: We found positive associations between BC exposure and 8-OHdG and MDA, in which associations with 8-OHdG were stronger in obese participants. These results suggest that exposure to low levels of traffic-related pollution results in lipid peroxidation and oxidative DNA damage in individuals with COPD.},
	keywords = {copd, pollution, Urinary oxidative stress},
	isbn = {1873-6750 (Electronic)0160-4120 (Linking)},
	author = {Grady, S. T. and Koutrakis, P. and Hart, J. E. and Coull, B. A. and Schwartz, J. and Laden, F. and J.J. Zhang and Gong, J. and Moy, M. L. and Garshick, E.}
}
