@article {18192,
	title = {Hydrogen Sulfide Prevents and Partially Reverses Ozone-Induced Features of Lung Inflammation and Emphysema in Mice},
	journal = {Am J Respir Cell Mol Biol},
	volume = {55},
	number = {1},
	year = {2016},
	note = {Li, FengZhang, PengyuZhang, MinLiang, LiSun, XiaoyuanLi, MinTang, YueqinBao, AihuaGong, JichengZhang, JunfengAdcock, IanChung, Kian FanZhou, XinengResearch Support, Non-U.S. Gov{\textquoteright}tAm J Respir Cell Mol Biol. 2016 Jul;55(1):72-81. doi: 10.1165/rcmb.2015-0014OC.},
	month = {Jul},
	pages = {72-81},
	edition = {2016/01/06},
	abstract = {Hydrogen sulfide (H2S), a novel signaling gasotransmitter in the respiratory system, may have antiinflammatory properties in the lung. We examined the preventive and therapeutic effects of H2S on ozone-induced features of lung inflammation and emphysema. C57/BL6 mice were exposed to ozone or filtered air over 6 weeks. Sodium hydrogen sulfide (NaHS), an H2S donor, was administered to the mice either before ozone exposure (preventive effect) or after completion of 6 weeks of ozone exposure (therapeutic effect). The ozone-exposed mice developed emphysema, measured by micro-computed tomography and histology, airflow limitation, measured by the forced maneuver system, and increased lung inflammation with augmented IL-1beta, IL-18, and matrix metalloproteinase-9 (MMP-9) gene expression. Ozone-induced changes were associated with increased Nod-like receptor pyrin domain containing 3 (NLRP3)-caspase-1 activation and p38 mitogen-activated protein kinase phosphorylation and decreased Akt phosphorylation. NaHS both prevented and reversed lung inflammation and emphysematous changes in alveolar space. In contrast, NaHS prevented, but did not reverse, ozone-induced airflow limitation and bronchial structural remodeling. In conclusion, NaHS administration prevented and partially reversed ozone-induced features of lung inflammation and emphysema via regulation of the NLRP3-caspase-1, p38 mitogen-activated protein kinase, and Akt pathways.},
	keywords = {*emphysema, *hydrogen sulfide, *lung inflammation, *ozone exposure, Animals, Biomarkers/metabolism, Blotting, Western, Bronchi/pathology, Bronchoalveolar Lavage Fluid, Caspase 1/metabolism, Caspase 3/metabolism, Enzyme Activation, Hydrogen Sulfide/pharmacology/*therapeutic use, Imaging, Three-Dimensional, Intracellular Signaling Peptides and Proteins/metabolism, Mice, Inbred C57BL, Oxidants/metabolism, Ozone/*adverse effects, p38 Mitogen-Activated Protein Kinases/metabolism, Phosphorylation, Pneumonia/*complications/diagnostic imaging/*drug therapy/physiopathology, Proto-Oncogene Proteins c-akt/metabolism, Pulmonary Emphysema/*complications/diagnostic imaging/*drug, Respiratory Function Tests, RNA, Messenger/genetics/metabolism, therapy/physiopathology, X-Ray Microtomography},
	isbn = {1535-4989 (Electronic)1044-1549 (Linking)},
	author = {Li, F. and P. Zhang and Zhang, M. and Liang, L. and Sun, X. and M. Li and Y. Tang and Bao, A. and Gong, J. and J. Zhang and Adcock, I. and Chung, K. F. and X. Zhou}
}
