<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yan Zhang</style></author><author><style face="normal" font="default" size="100%">Su, Zhiguo</style></author><author><style face="normal" font="default" size="100%">Qiu, Xuyang</style></author><author><style face="normal" font="default" size="100%">Liu, He</style></author><author><style face="normal" font="default" size="100%">Wen, Donghui</style></author><author><style face="normal" font="default" size="100%">Lyujun Chen</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Distinct ARG profiles associated with class 1 integrons in municipal and industrial wastewater treatment plants</style></title><secondary-title><style face="normal" font="default" size="100%">Environmental Science and Ecotechnology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibiotic resistance genes (ARGs)</style></keyword><keyword><style  face="normal" font="default" size="100%">Class 1 integrons</style></keyword><keyword><style  face="normal" font="default" size="100%">High-throughput qPCR</style></keyword><keyword><style  face="normal" font="default" size="100%">PacBio sequencing</style></keyword><keyword><style  face="normal" font="default" size="100%">Wastewater treatment plants (WWTPs)</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.sciencedirect.com/science/article/pii/S266649842500064X</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">26</style></volume><pages><style face="normal" font="default" size="100%">100586</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Class 1 integrons facilitate horizontal gene transfer, significantly influencing antibiotic resistance gene (ARG) dissemination within microbial communities. Wastewater treatment plants (WWTPs) are critical reservoirs of ARGs and integrons, yet the integron-mediated dynamics of ARG transfer across different WWTP types remain poorly understood. Here we show distinct ARG profiles associated with class 1 integrons in municipal and industrial WWTPs using a novel approach combining nested-like high-throughput qPCR and PacBio sequencing. Although industrial WWTPs contained higher absolute integron abundances, their relative ARG content was lower (1.27 × 107–9.59 × 107 copies/ng integron) compared to municipal WWTPs (3.72 × 107–1.98 × 108 copies/ng integron). Of the 132,084 coding sequences detected from integrons, 56.8 % encoded antibiotic resistance, with industrial plants showing lower ARG proportions, reduced ARG array diversity, and greater incorporation of non-ARG sequences. These findings suggest industrial WWTP integrons integrate a broader array of exogenous genes, reflecting adaptation to complex wastewater compositions. This work enhances our understanding of integron-driven ARG dynamics in wastewater and offers a robust strategy for environmental integron analysis.</style></abstract></record></records></xml>