@article {LI2025117731,
	title = {Historical distribution and multi-dimensional environmental risk assessments of antibiotics in coastal sediments affected by land-based human activities},
	journal = {Marine Pollution Bulletin},
	volume = {214},
	year = {2025},
	pages = {117731},
	abstract = {Coastal sediment cores provide important records of land-based antibiotics\&$\#$039; deposition. This study examined sediment cores from the Hangzhou Bay, East China Sea, dating back to 1980{\textendash}2020 using 210Pbex. The 40-year analysis revealed a mismatch between sediment depth and age. Wastewater treatment facilities have significantly reduced antibiotics discharge into the sea. We identified 27 antibiotics, with enrofloxacin (ERFX) and nadifloxacin (NDFX) exhibiting the highest average concentrations of 84.9 and 83.4~ng/g, respectively. Quinolones (QNs) were prominent, displaying strong co-occurrence and similar distribution patterns shaped by comparable soil-water distribution coefficient (Kd). QNs correlated positively with total antibiotic concentration, serving as indicators. We proposed a multi-dimensional risk assessment of antibiotics, encompassing ecological and antimicrobial resistance (AMR) risks, complementing each other. The assessment revealed antibiotics with distinct risks: sulfacetamide (SCM) and clindamycin (CLIN) exhibited high ecological risks, while ERFX, ciprofloxacin (CFX), norfloxacin (NFX), gatifloxacin (GTFX), moxifloxacin (MXFX), and marbofloxacin (MBFX) presented high AMR risks.},
	keywords = {Antibiotics, Antimicrobial resistance risks, Coastal sediment cores, Ecological risks, Historical distribution},
	issn = {0025-326X},
	doi = {https://doi.org/10.1016/j.marpolbul.2025.117731},
	url = {https://www.sciencedirect.com/science/article/pii/S0025326X25002061},
	author = {Feifei Li and Lyujun Chen and Su, Zhiguo and Yuhan Zheng and Cao, Feng and Yang, Wendy and Wen, Donghui}
}
