@article {33745,
	title = {Screening of priority antibiotics in Chinese seawater based on the persistence, bioaccumulation, toxicity and resistance},
	journal = {Environment	International},
	volume = {179},
	year = {2023},
	pages = {108140},
	abstract = {Antibiotics are emerging pollutants that have detrimental effects on both target and non-target organisms in the environment. However, current methods for environmental risk assessment primarily focus on the risk to non-target organisms in ecosystems, overlooking a crucial risk of antibiotics - the induction of resistance in targeted bacteria. To address this oversight, we have incorporated resistance (R) risk with persistence, bioaccumulation and toxicity (PBT) to establish a more comprehensive PBTR (persistence, bioaccumulation, toxicity, and resistance) framework for antibiotic-specific risk assessment. Using the PBTR framework, we evaluated 74 antibiotics detected in Chinese seawater from 2000 to 2021, and identified priority antibiotics. Our analysis revealed that the priority antibiotics with R risk accounted for the largest proportion (50\% to 70\%), followed by P risk (40\% to 58\%), T risk (16\% to 35\%) and B risk (0 to 13\%). To further categorize these priority antibiotics, we assigned them a risk level according to their fulfillment of criteria related to P, B, T, and R. Antibiotics meeting all four indicators were classified as Grade I, representing the highest risk level. Grade II and Grade III were assigned to antibiotics meeting three or two indicators, respectively. Antibiotics meeting only one indicator were classified as Grade IV, representing the lowest risk level. The majority of priority antibiotics fell into Grade IV, indicating low risk (55\% to 79\%), followed by Grade III (16\% to 45\%). The highest risk antibiotic identified in this study was clindamycin (CLIN), categorized as Grade II, in the East China Sea. Our findings aligned with previous studies for 25 antibiotics, affirming the validity of the PBTR framework. Moreover, we identified 13 new priority antibiotics, highlighting the advancement of this approach. This study provides a feasible screening strategy and monitoring recommendations for priority antibiotics in Chinese seawater.},
	keywords = {Priority antibiotics; Resistance; Environment risk assessment; PBTR framework; Seawater},
	url = {https://www.sciencedirect.com/science/article/pii/S0160412023004130},
	author = {Feifei Li and Yingyu Bao, and Lyujun Chen and Su, Zhiguo and Tang, Yushi and Wen, Donghui}
}
